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Hasan Baber

Hasan Baber

Dow University of Health Sciences, Pakistan

Title: Variations in mineral crystallites of bone at distinct skeletal sites and its relationship with diseases like osteoporosis


Biography: Hasan Baber


Introduction: Human bone forms the skeleton framework of the body. The mineral component of bone together with the orientation of its crystallites at different levels of Hierarchy is responsible for the mechanical strength and resistance of bone to external stresses and strains. Studies have revealed that among various bones, calvaria are seen to be more resistant to mechanical stresses and bone diseases like osteoporosis.

Aim & Materials: To investigate the property of skull bone, we took post-pubescent rat samples of ulna, calvaria and whale rostrum.

Methods: The collected samples were analyzed through, Synchrotron X-ray diffraction. We put the bone samples into XMAS beam line for the interpretation of data through synchrotron. We then analyzed the interpreted data by ESRF (European Synchrotron Radiation Facility) software, Fit2d and fitted the curves by ORIGINS and SIGMAPLOT for plotting the graphs. We then did SEM of the rat ulna and calvaria samples and the images for whale rostrum were collected (images courtesy of Zhen Li and Jill Pasteris at University of Washington) and compared.

Results: Our results demonstrated a greater orientation of crystallites in rat calvaria and whale rostrum, than in ulna samples. This increased orientation may be due to functional adaptability, age and the amount of external stresses, which cause this bone to be resistant.

Conclusion: In summary we have shown that the resistance offered by skull bones to stresses and strains and diseases like osteoporosis is partly due to the orientation of the bone crystallites.

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